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Morinaga Milk’s probiotic B. breve A1 improves memory functions of older adults with MCI

Morinaga Milk Industry Co., Ltd., a number one Japanese dairy product firm and a key international probiotics producer, confirmed that its proprietary probiotic pressure Bifidobacterium breve A1 (a.okay.a. B. breve MCC1274) is protected and efficient for enhancing memory functions of older adults with suspected gentle cognitive impairment (MCI) in a randomized, double-blind, placebo-controlled trial (RCT).

Morinaga Milk’s probiotic B. breve A1 improves memory functions of older adults with MCI

Changes of RBANS scores at 16 weeks from baseline. Values are indicated as imply with error bars as the usual error. **p<0.001, ***p<0.0001, inter-group distinction, Student’s t-test. (Graphic: Business Wire)

The new examine, printed lately within the Journal of Alzheimer’s Disease, has produced breakthrough outcomes uncovering a novel promising probiotic intervention for early dementia prevention. The medical examine carried out by a medical analysis group, Huma R&D Co., Ltd. in Tokyo, Japan, in collaboration with Morinaga Milk Industry Co., Ltd, is the primary RCT report to indicate a profound cognitive enhancement profit of the probiotic B. breve A1 in topics with suspected MCI.

Our findings signify an essential breakthrough for MCI and dementia prevention. It marks main progress in our investigation on the power of the probiotic pressure B. breve A1 to halt the cognitive decline of older adults.”


Dr. Xiao, Director of Next Generation Science Institute of Morinaga Milk, and Principal Investigator of the Trial

Globally, the quantity of individuals residing with dementia, together with Alzheimer’s illness, will enhance from 50 million in 2018 to 152 million in 2050, reaching epidemic proportions. According to the Alzheimer’s Association web site, it’s estimated that one new affected person is identified with Alzheimer’s illness each 65 seconds (https://www.alz.org/alzheimers-dementia/facts-figures), inflicting an unprecedented burden to society.

MCI is a typical drawback in older adults related with the danger of creating sporadic Alzheimer’s illness or different dementia inside a couple of years if left untreated. Currently, no drugs have confirmed efficient for MCI. Although a number of trials of pharmacological remedies have been thought to forestall the signs of MCI, the outcomes have been disappointing. Hence, there’s an pressing must establish efficient countermeasures to MCI and dementia.

Previous research by Morinaga Milk Industry Co., Ltd. have demonstrated the potential of B. breve A1 to deal with Alzheimer’s illness in a pre-clinical mannequin and located that this probiotic pressure can enhance particular cognitive functions in topics with MCI in a human medical trial. The present examine carried out on 80 wholesome older adults with suspected MCI additional confirmed the efficacy of B. breve A1 on cognitive enchancment.

Remarkable enchancment in RBANS whole rating

Participants randomly obtained both B. breve A1 or placebo by capsule for 16 weeks. At the tip of the examine, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) whole rating confirmed a big 11.3-point enchancment in these taking A1 in comparison with placebo, specifically for area scores of quick memory, visuospatial/constructional, and delayed memory. In addition, important enchancment of cognitive operate was confirmed by one other take a look at, the Japanese model of the MCI Screen.

Dr. Xiao stated, “It was exciting to see a clear and significant improvement of memory functions such as the awareness of who, when, and where. The 11.3-point improvement of RBANS total score seen after only 16 weeks of daily consumption of the probiotic B. breve A1 in healthy older adults with MCI is remarkable.”

“Our findings could signal a profound shift as to how MCI can be treated using probiotics. Future discoveries for the precise mechanisms as to how daily consumption of B. breve A1 can improve memory will open new opportunities and alternatives for not only MCI treatment but perhaps also for other CNS diseases associated with inflammation and memory impairment.”

First proof of HRB probiotics in enhancing cognitive operate of MCI and supporting wholesome cognitive growing older

Pioneer in bifidobacteria analysis, Morinaga Milk has been specializing in the examine of bifidobacteria species which are naturally current in human intestines – human-residential bifidobacteria (HRB) – for over 50 years and found varied well being advantages of its HRB strains. To proceed exploring the potential of its HRB strains, lately, the corporate has targeted on the gut-brain connection – a quickly rising space of probiotics analysis – and carried out varied analysis on cognitive enchancment.

Embracing a big milestone, Morinaga Milk is delighted to have uncovered the useful results of its proprietary probiotic B. breve A1 on memory enchancment. B. breve A1 originating from new child infants’ intestines is the primary human-residential bifidobacteria (HRB) pressure that exhibits nice promise to enhance the memory of older adults with MCI and help wholesome cognitive growing older.

This breakthrough examine is one more indication of our steady efforts so as to add worth to our premium line of HRB probiotic strains. This promising discovering will open up new enterprise alternatives and is probably game-changing. We are excited in regards to the potential implications of B. breve A1 as a novel sensible strategy to advertise wholesome growing older.”


Ko Shiino, General Manager of Sales and Marketing Department, International Division of Morinaga Milk



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