New analysis revealed within the Facilities for Illness Management and Prevention’s journal Emerging Infectious Diseases has confirmed the emergence of a brand new extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant known as HMN.19B from the viral clade 19B in France. The 19B viral clade — which incorporates the D614G variant — was prevalent in late 2019 however had since been hardly ever noticed since early 2020 due to newer viral clades.
The variant is characterised by 18 amino acid mutations — together with N501Y, L452R, and H655Y. There may be proof the variant can unfold extra quickly than different SARS-CoV-2 strains.
The researchers write:
Whether or not HMN.19B can be much less vulnerable to safety by pure, therapeutic, or vaccine-induced immune responses stays to be decided. A number of of its spike substitutions (N501Y, L452R, and H655Y) have been proven to require increased ranges of neutralizing antibodies to be managed, each in vitro and in vivo.”
Contemplating the restricted knowledge obtainable on this new variant, the research authors emphasize an elevated want for genomic surveillance and monitoring.
Preliminary Detection of HMN.19B variant
Researchers have been alerted to a brand new SARS-CoV-2 variant of curiosity on January 21, 2021, from PCR testing of an immunocompromised hospital employees member who offered with headache, fatigue, and rhinitis. Her accomplice in the identical family and two nurses in shut contact additionally examined constructive for the variant. All 4 sufferers skilled delicate signs and didn’t require hospitalization.
The hospital employees member and accomplice had a historical past of COVID-19 an infection, however each had examined detrimental for SARS-CoV-2 protein N antibodies in January 2021. One of many nurses had obtained their first Pfizer-BioNTech vaccine dose 11 days earlier than testing constructive for the virus.
Genomic surveillance of the variant
Genomic sequencing confirmed 4 cluster members contaminated with a brand new variant associated to clade 19B.
The variant comprises 25 nucleotide substitutions, together with 2 deletions and eight amino acid substitutions on the SARS-CoV-2 spike protein.
Unfold of the HMN.19B variant in Paris
4 weeks after, researchers recognized the HMN.19B variant within the genomic sequencing of 12 individuals residing in Paris who examined constructive for COVID-19 an infection. This included a jail employees employee working within the northeast space of Paris, three from the hematology division of a hospital, and eight unrelated circumstances on February 3-23 in numerous Paris hospitals.
Concurrently, the Nationwide Reference Middle for Respiratory Viral Infections in Lyon, France, detected 17 extra individuals with carefully associated viruses to the HMN.19B variant. The associated viruses contained greater than seven related spike protein mutations. Three individuals have been from the larger Paris space, 10 from southeastern France, and four from southwestern France.